Determination of the Association of Haptoglobin 2-2 With Delirium After Orthopedic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 8
- 主要终点
- Postoperative delirium duration
研究概览
简要总结
Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and inflammation. Investigators will then analyze the data to see if haptoglobin 2-2 type is associated with an increased postoperative delirium, inflammation and oxidative stress.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I to III class for major orthopedic surgery (hip or knee replacement or spinal surgery)
- •No psychological and psychiatric history and presentation before surgery
- •No major organ dysfunction or failure
排除标准
- •Anemia (hemoglobin < 100 g/l) preoperatively.
- •Requires > 4 units of allogeneic red blood cell transfusion during the surgery
- •Using steroids or anti-psychological and anti-psychiatric drugs. A small dose of steroid for postoperative anti-nausea/vomiting is allowed and will not be considered as a indication for exclusion.
- •Can not cooperate with the study
- •History of bleeding
- •BMI < 18 or > 30
- •History of hemoglobin metabolism disorder
结局指标
主要结局
Postoperative delirium duration
时间窗: From day 0 to up to 7 days after the surgery
The duration of delirium as assessed by intensive care unit-confusion assessment method will be determined.
Postoperative delirium incidence
时间窗: From day 0 to up to 7 days after the surgery
The incidence of delirium as assessed by intensive care unit-confusion assessment method will be determined.
次要结局
- Oxidative stress level(Day 0 to day 2 after the surgery)
- Inflammation level(Day 0 to day 2 after the surgery)
研究者
Zhiyi Zuo
Visiting Professor
Sun Yat-sen University