CTRI/2023/04/051712
Active, not recruiting
未知
A prospective study to evaluate the efficacy of oral pilocarpine in radiation induced Xerostomia among patients with head and neck squamous cell carcinoma - PRIX
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
- Sponsor
- SVIMS
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Histo pathologically proven squamous cell carcinoma of head \& neck \[oral cavity, oropharynx, nasopharynx, hypopharynx, larynx]
- •Age : 18 \-70 years
- •Patients with ECOG performance status of 0\-2
- •Stage I to IVb \[AJCC : 8th edition]
- •Patients receiving definitive or adjuvant RT (postoperative cases) with or without concurrent chemotherapy
- •Patients who have given approved informed consent
Exclusion Criteria
- •Patients previously treated with radiotherapy to head \& neck region
- •Patients receiving palliative radiotherapy
- •Cancers of salivary glands
- •Patients with surgical removal of parotid / submandibular glands
- •Patients with ECOG performance status of 3\-4 \[Appendix II]
- •Patients allergic to pilocarpine
- •Patients receiving tricyclic antidepressants, beta blockers \& anti histaminics
- •Patients suffering with closed angle glaucoma, asthma, COPD \& coronary artery disease
- •Pregnant \& lactating women
Outcomes
Primary Outcomes
Not specified
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