A clinical trial to study the effect of drug pilocarpine in radiation induced dryness of mouth among patients with head and neck cancers
- Conditions
- Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
- Registration Number
- CTRI/2023/04/051712
- Lead Sponsor
- SVIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Histo pathologically proven squamous cell carcinoma of head & neck [oral cavity, oropharynx, nasopharynx, hypopharynx, larynx]
Age : 18 -70 years
Patients with ECOG performance status of 0-2
Stage I to IVb [AJCC : 8th edition]
Patients receiving definitive or adjuvant RT (postoperative cases) with or without concurrent chemotherapy
Patients who have given approved informed consent
Patients previously treated with radiotherapy to head & neck region
Patients receiving palliative radiotherapy
Cancers of salivary glands
Patients with surgical removal of parotid / submandibular glands
Patients with ECOG performance status of 3-4 [Appendix II]
Patients allergic to pilocarpine
Patients receiving tricyclic antidepressants, beta blockers & anti histaminics
Patients suffering with closed angle glaucoma, asthma, COPD & coronary artery disease
Pregnant & lactating women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Stimulated and unstimulated Salivary flowTimepoint: 3 months
- Secondary Outcome Measures
Name Time Method Visual Analog ScoreTimepoint: 3 months