Effects of CO2 infrared laser moxibustion on patients with knee osteoarthritis

Not Applicable

Completed

• Conditions: Patients with knee osteoarthritis; Musculoskeletal Diseases; Gonarthrosis [arthrosis of knee]

• Registration Number: ISRCTN26065334
• Lead Sponsor: Shanghai University of Traditional Chinese Medicine (China)

Brief Summary

2020 results in https://pubmed.ncbi.nlm.nih.gov/31446581/ (added 17/12/2020)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2011-07-31
• Study Start: 2013-09-06
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 190

Inclusion Criteria

1. Middle-aged and aged individuals, aged 50 years or older, male or female
2. According to the knee OA diagnostic criteria of the American College of Rheumatology, radiographic evidence of at least 1 osteophyte at the tibiofemoral joint (Kellgren?Lawrence grade II or III)
3. Moderate or greater clinically significant knee pain on most days during the past month
4. No acupuncture or moxibustion treatment received in the previous 3 months
5. Willingness to be randomly assigned; understanding and signing the informed consent

Exclusion Criteria

1. Diagnosis with inflammatory arthritis, gout, acute knee joint injury or other knee arthritis (without cartilage involvement), meniscus injury, ligament injury and intra-articular fracture
2. Presence of serious heart diseases, kidney diseases, liver diseases or malignant tumors (unless the patient was surgically treated and with no relapse more than 5 years), systemic infection or contagious diseases
3. Intra-articular corticosteroid or hyaluronate injections (as well as any knee surgery or topical use of medication) during the past 6 months, or previous history of knee surgery
4 Previous experience with drug tests

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
WOMAC (VAS3.1) Questionnaire was applied to assess the therapeutic effects in terms of joint pain, stiffness, and functional disorder of the participants after 2 weeks and 4 weeks of the treatment initiation, and the long-term effects were also assessed 4 weeks post-treatment.

Secondary Outcome Measures

Name	Time	Method
The 50-yard walking time was assessed and recorded among the participants after 2 weeks and 4 weeks of the treatment as well as 4 weeks post-treatment to observe improvements in walking. In the follow-up, we asked the participants to assess their therapeutic effects and guess their group assignment to assess the masking effectiveness of the trial. Additionally, the participants would also be asked whether they thought the treatment were safe.