A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study mechanisms of blood pressure lowering of losartan, Moxonidine and Low sodium diet in former pre-eclamptic wome
- Conditions
- Preeclampsia
- Registration Number
- NL-OMON28431
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
1.Patient is a female between 18 and 45 years of age on the day of signing informed consent.
2.Have a recent history of preeclampsia that is defined as gestational hypertension and concomitant proteinuria in the second half of pregnancy. Gestational hypertension was defined according to the criteria of the International Society for the Study of Hypertension in Pregnancy (ISSHP) as diastolic blood pressure above 90 mmHg and/or systolic blood pressure above 140 mmHg, measured on two or more separate occasions at least 4 hours apart. Proteinuria was diagnosed with urinary protein was above 300 mg per 24 hour or above 2+ at dipstick urinalysis 17
1.SBP > 180 mmHg and/or DBP > 110 mmHg during one or more screening measurements.
2.Current pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mean 24-hour SBP/DBP, mean day/night time SBP/DBP
- Secondary Outcome Measures
Name Time Method mean intrapersonal changes in endothelial function (FMD), serum lipid concentrations, HOMA, central blood pressure (PWA), serum and urine concentrations of markers of oxidative stress, serum concentrations of markers of systemic inflammation, arterial stiffness (PWV, PWA), RAAS-hormone concentrations, HRV, 24hr urine measurements