The Standard Concentration of Morphine as a Positive Control for Intradermal Skin Test

Completed

• Conditions: Intradermal Test

• Registration Number: NCT00853476
• Lead Sponsor: Chulalongkorn University

Brief Summary

This study aims to compare skin reactivity results between morphine and histamine as a positive control agents in intradermal skin test.

Detailed Description

Histamine hydrochloride and different concentrations of morphine sulfate will be intradermally injected and wheal diameter size will be comparatively measured between 15-30 minutes' time points after the test.

Study Timeline

• Study First Submitted: 2009-02-27
• Study First Submitted QC: 2009-02-27
• Study Start: 2009-03
• Study First Posted: 2009-03-02
• Primary Completion: 2009-10
• Study Completion: 2009-10
• Status Verified: 2011-02
• Last Update Submitted: 2011-02-16
• Last Update Posted: 2011-02-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• age 18-60 years old

Exclusion Criteria

• immunodeficiency state
• cancer
• severe skin diseases
• severe medical illnesses
• malnutrition
• uncontrolled asthma
• pregnancy
• received oral or systemic corticosteroid within 1 month before this study
• receiving immunosuppressive agents
• taken antihistamine within 3 days before this study
• taking beta-blocker
• previous history of immunotherapy
• have hypersensitivity reaction to morphine/opiates

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Wheal diameter from morphine skin test at different concentrations compared to standard histamine between 15-30 minutes after skin test	30 minutes

Secondary Outcome Measures

Name	Time	Method
Side effects	24 hours

Trial Locations

Locations (1)

Faculty of Medicine, Chulalongkorn University; 🇹🇭 Bangkok, Thailand