The Detection Of Circulating Tumor Cells (CTC) In Patients With NSCLC Undergoing Definitive Radiotherapy Or Chemoradiotherapy
Completed
- Conditions
- Non-small Cell Lung Cancer
- Interventions
- Radiation: Radiotherapy
- Registration Number
- NCT02135679
- Lead Sponsor
- Abramson Cancer Center at Penn Medicine
- Brief Summary
CTC levels collected pre-surgery will be correlated with pathological samples.
- Detailed Description
Patients with NSCLC who undergo radiation as part of a definitive course of treatment will be enrolled. Blood collections will be obtained before, during, and after radiotherapy. We will collect demographic and treatment data and explore \& describe the pattern of CTC detection in all patients
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 204
Inclusion Criteria
- Patients with biopsy-proven NSCLC who are undergoing definitive radiotherapy as a part of their treatment regimen.
- Age 18 or older
- Signed informed consent
- Patients who are incapable of providing informed consent are excluded from participating in this study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cohort 6 Radiotherapy (Patients with suspected (no tissue diagnosis) early stage NSCLC undergoing stereotactic radiotherapy) Cohort 1 Radiotherapy Patients with early stage NSCLC undergoing stereotactic radiotherapy Cohort 3 Radiotherapy Patients with stage I-III NSCLC undergoing standard, fractionated radiotherapy alone Cohort 5 Radiotherapy Patients with resectable stage IIIa NSCLC undergoing pre-operative chemoradiotherapy Cohort 4 Radiotherapy Patients with locally advanced NSCLC undergoing standard chemoradiotherapy with the novel signal transduction inhibitor, nelfianvir. Cohort 2 Radiotherapy Patients with locally advanced NSCLC undergoing standard chemoradiotherapy
- Primary Outcome Measures
Name Time Method To Describe the Pattern of CTCs Before and After Definitive Radiotherapy for Each Treatment Stratum 24 months The pattern of CTCs before and after definitive radiotherapy for each treatment stratum. CTC counts per mL before and after definitive radiotherapy.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Abramson Cancer Center of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States