The Influence of Oxytocin on the Processing of Social Contact
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Pleasantness ratings of social touch
研究概览
简要总结
Social touch can convey the most potent and salient of socio-emotional signals. While the hypothalamic peptide oxytocin (OXT) has been identified as a key neurochemical mediator of grooming in some other social species, its modulatory influence on human interpersonal touch is unknown. The investigators expect that OXT augments the hedonic value of touch and that this behavioral effect is paralleled at the neural level by an increased response in brain areas mediating rewarding aspects of social touch.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers
排除标准
- •Current or past psychiatric disease Current or past physical illness Psychoactive medication Tobacco smokers
研究组 & 干预措施
Oxytocin
24 IU Oxytocin, intranasal application 30 min prior to the experiment
干预措施: Oxytocin (Drug)
Placebo
intranasal application, sodium chloride solution, 3 puffs per nostril
干预措施: Placebo (Drug)
结局指标
主要结局
Pleasantness ratings of social touch
时间窗: 30 minutes after the nasal spray administration
After each trial, subjects are asked to use a visual analog scale to rate the pleasantness of the administered touch.
Blood-oxygen-level dependent signal in response to social touch
时间窗: 30 minutes after the nasal spray administration
By using functional magnetic resonance imaging we want to examine oxytocin's effects on the neural correlates (BOLD signal) of social touch.
次要结局
- Questionnaire measurement of mood (PANAS) and anxiety (STAI).(15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment)
研究者
Rene Hurlemann
MD PhD M.Sc.
University Hospital, Bonn