Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars

Not Applicable

Completed

• Conditions: Third Molars Extraction

• Registration Number: NCT06880952
• Lead Sponsor: Isala

Brief Summary

This study aimed to assess the impact of postoperative chlorhexidine use on pain management following mandibular third molar removal

In this prospective, randomized controlled trial,130 patients who underwent mandibular third molar surgical removal were divided into two groups: one group used chlorhexidine for postoperative rinsing and the other did not rinse. Pain levels, measured using the Numeric Rating Scale (NRS), were recorded daily for the first seven days post-surgery. Paired-samples t-tests were utilized for data analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-01
• Primary Completion: 2022-03-24
• Study Completion: 2022-08-19
• Status Verified: 2025-03
• Study First Submitted: 2025-03-10
• Study First Submitted QC: 2025-03-17
• Last Update Submitted: 2025-03-17
• Study First Posted: 2025-03-18
• Last Update Posted: 2025-03-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 145

Inclusion Criteria

• healthy adults (18+) referred by their dentist for third molar removal

Exclusion Criteria

• active pericoronitis or other infections
• planned coronectomy
• trismus
• chronic pain
• pregnancy
• known allergies to local anesthesia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Postoperative pain after removal of third molar	7 days after the inclusion pain was measured on a numerical rating scale	The primary endpoint is the difference in the postoperative pain measured on a numerical rating scale (NRS) evaluated at seven days

Secondary Outcome Measures

Name	Time	Method
Post-operative complications	7 days after the treatment the patient was seen at the outpatient clinic for clinical assessment. At this moment the number of patients with alveolitis, foodimpaction and bleeding was scored.	As secondary outcome measures alveolitis, foodimpaction, bleeding or infection

Trial Locations

Locations (1)

Isala Hospital; 🇳🇱 Zwolle, Overijssel, Netherlands