Effect of Post-operative Chlorhexidine on Postoperative Pain and Complications After Surgical Removal of Mandibular Third Molars: a Randomized Controlled Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Isala
- Enrollment
- 145
- Locations
- 1
- Primary Endpoint
- Postoperative pain after removal of third molar
Study Overview
Brief Summary
This study aimed to assess the impact of postoperative chlorhexidine use on pain management following mandibular third molar removal
In this prospective, randomized controlled trial,130 patients who underwent mandibular third molar surgical removal were divided into two groups: one group used chlorhexidine for postoperative rinsing and the other did not rinse. Pain levels, measured using the Numeric Rating Scale (NRS), were recorded daily for the first seven days post-surgery. Paired-samples t-tests were utilized for data analysis.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy adults (18+) referred by their dentist for third molar removal
Exclusion Criteria
- •active pericoronitis or other infections
- •planned coronectomy
- •chronic pain
- •pregnancy
- •known allergies to local anesthesia
Arms & Interventions
No post-operative rinsing
Those allocated to the control group received no post-operative rinsing
Post-operative rinsing with chlorhexidine
In the rinsing group, the patients received a bottle of 0,2% chlorhexidine
Intervention: Chlorhexidine Digluconate Mouthwash without Alcohol (Other)
Outcomes
Primary Outcomes
Postoperative pain after removal of third molar
Time Frame: 7 days after the inclusion pain was measured on a numerical rating scale
The primary endpoint is the difference in the postoperative pain measured on a numerical rating scale (NRS) evaluated at seven days
Secondary Outcomes
- Post-operative complications(7 days after the treatment the patient was seen at the outpatient clinic for clinical assessment. At this moment the number of patients with alveolitis, foodimpaction and bleeding was scored.)
Investigators
Jeroen van der Sleen
Oral Surgeon and Principal Investigator
Isala