Fatty Acid Biomarkers of Carbohydrate Intake

Not Applicable

Completed

• Conditions: Dyslipidemias

• Registration Number: NCT03295448
• Lead Sponsor: Uppsala University

Brief Summary

The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Detailed Description

In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.

Study Timeline

• Study First Submitted: 2017-09-22
• Study First Submitted QC: 2017-09-22
• Study First Posted: 2017-09-27
• Study Start: 2017-10-25
• Primary Completion: 2018-06-01
• Study Completion: 2018-06-01
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-14
• Last Update Posted: 2018-11-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• BMI 20-38

Exclusion Criteria

• abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Palmitic acid in different plasma fractions	14-20 days	Measured by liquid gas chromatography (GC)

Secondary Outcome Measures

Name	Time	Method
Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids	14-20 days	Measured by liquid GC

Trial Locations

Locations (1)

Uppsala univeristy hospital; 🇸🇪 Uppsala, Sweden