Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Urethral Strictures
- Sponsor
- Sheba Medical Center
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- post operative clinical & imaging signs of urinary outflow obstruction or partial obstruction
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to determine whether laser internal urethrotomy (IU) is as efficient as cold knife internal urethrotomy for treatment of anterior urethral strictures regarding post operative urination outflow, stricture recurrence rate and possible post- operative complications
Detailed Description
The current surgical treatment for anterior urethral stricture includes internal urethrotomy (IU) by cold knife. Recurrence rate after such procedure is quoted as 35-70% in 2 to 5 years follow-up. Possible surgical alternative procedures include: open surgical urethral re-construction, urethral stents usage \& laser IU. According to existing data (Nd-YAG laser- retrospective) the recurrence rate after laser IU is far better comparing to cold knife urethrotomy. The current research intends to address this question using prospective randomized methods.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men over 18 years old with urethral stricture
Exclusion Criteria
- •S/P urethral reconstruction
- •Posterior urethral strictures
Outcomes
Primary Outcomes
post operative clinical & imaging signs of urinary outflow obstruction or partial obstruction
Time Frame: up to 2 years
Urethral stricture \& urinary flow will be assessed by physical examination, urethrography, cystoscopy, sonographic bladder scan for urine rest, urine flowmetry \& clinical questionnaire (IPSS).
Secondary Outcomes
- post operative complications(up to 2 years)