A prospective observational study to find out correlation of serum antiepileptic drug (AED) and biomarkers levels with seizure recurrence in persons with epilepsy (PWE) undergoing AED tapering

All India Institute of Medical Sciences New Delhi0 个研究点目标入组 330 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1. Clinically diagnosed persons with epilepsy (PWE)
•2. Either male or female, age more than 18 years
•3. On monotherapy of AEDs (valproic acid, carbamazepine, phenytoin and levetiracetam)
•4. Two years seizure freedom or longer
•5. PWE going to start AED tapering
•6. Patient ready to give informed consent

•1. Juvenile myoclonic epilepsy
•2. Pregnant or seeking pregnancy
•3. Associated neurological diseases other than epilepsy
•4. Patient on drugs known to alter seizure threshold (e.g. INH, theophylline, metronidazole etc.)
•5. Patient with significant hepatic and renal impairment that may require dose alteration
•6. Patient on anti tubercular drugs or any other drugs known to cause interaction with AEDs (e.g. isoniazid, fluoxetine, fluvoxamine, clarithromycin, erythromycin, fluconazole etc.)
•7. Patient on food or dietary supplements like grape fruit juice and ginkgo biloba which are known to cause interaction with AEDs
•8. Any associated psychiatric disorder
•9. Any chronic inflammatory disorder (e.g. Autoimmune disorder like RA, IBD, bronchial asthma)
•10. Patient refuses to give informed consent

发起方

All India Institute of Medical Sciences New Delhi