A Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Painful Diabetic Neuropathy

Phase 2

Completed

• Conditions: Neuropathic Pain
• Interventions: Drug: nitric oxide gel; Drug: placebo gel

• Registration Number: NCT01633086
• Lead Sponsor: China Medical University Hospital

Brief Summary

This is a randomized, double-blind, placebo-controlled, 2-period crossover, 12-week trial to be conducted in 50 subjects with painful diabetic neuropathy. The objective of this trial is to assess the safety and efficacy of NO gel, a NO donor, as compared with a placebo gel, in symptom relief of subjects with painful diabetic neuropathy.

Detailed Description

Neuropathic pain is a common symptom of diabetic neuropathy, and predominantly involves the lower limbs. Current strategies for the management of painful diabetic neuropathy include improved glycemic control, use of analgesics and addition of tricyclic antidepressants and anticonvulsants. However, many patients experience unsatisfactory responses and some undesired side effects. Considerable evidence implicates impaired nitric oxide synthesis plays an important role in the pathogenesis of diabetic neuropathic pain. Several small studies have shown that topical nitroglycerin ointment has local vasodilating properties, and a previous study has demonstrated that isosorbide dinitrate in spray form as a nitric oxide donor relieved some neuropathic symptoms in patients with painful diabetic neuropathy. Based on the findings, the investigators hypothesize that nitric oxide gel could be used as an alternative pain-relieving agent for patients with resistant diabetic neuropathic pain.

Study Timeline

• Study First Submitted: 2012-05-30
• Study First Submitted QC: 2012-06-29
• Study Start: 2012-07
• Study First Posted: 2012-07-04
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-11
• Last Update Posted: 2015-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

1. Subjects>=30 and<=80 years of age.
2. Subjects with type 1 or type 2 diabetes mellitus with painful diabetic neuropathy.
3. Subjects without undergoing treatment for painful diabetic neuropathy or with treatment for at least 3 months but still presenting neuropathic pain prior to randomization.
4. Subjects who are healthy without any serious diseases that require hospitalization during the study period.
5. Subjects who are capable of understanding and having signed the Informed Consent Form after detailed description of the treatment procedures and potential risks and benefits.

Exclusion Criteria

1. Subjects with diagnosis of cancer and are still on active therapies.
2. Subjects with diagnosis of an active disease (e.g. hyper-or-hypothyroidism, advanced chronic renal failure, severe anemia, liver cirrhosis, active infectious disease etc.) and are still under regular treatment for this disease
3. Subjects with peripheral neuropathy caused by a known acute or chronic disease or injury
4. Subjects who are on other medications with pharmacological actions that may lead to excessive formation of nitric oxide (e.g. sublingual nitroglycerin, sildanafil etc.) or may accentuate drug effects due to excessive formation of nitric oxide.
5. Subjects with severe peripheral artery disease leading to absence of foot pulses.
6. Subjects with erratic glycemic control (HbA1c 12).
7. Subjects with an active foot ulceration or infection.
8. Subjects with any known allergic reaction to any ingredient in the 2 gel preparations.
9. Subjects who have been enrolled into any clinical study in the preceding 3 months prior to randomization.
10. Subjects with current substance or alcohol abuse that in the opinion of the investigator would interfere with compliance or with interpretation of the study result
11. Female subject of childbearing potential who is lactating or has positive urine pregnancy test at V0 or refuses to adop reliable method of contraception during the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
nitric oxide gel	nitric oxide gel	1. st gel: sodium nitrites 2. nd gel: maleic/ascorbic acids
Placebo gel	placebo gel	1. st gel: phosphate-buffered saline 2. nd gel: maleic/ascorbic acids

Primary Outcome Measures

Name	Time	Method
Neuopathic Pain Scale	12 weeks

Secondary Outcome Measures

Name	Time	Method
vascular duplex parameters	12 weeks
the likelihood of reusing the nitric oxide gel recorded	12weeks

Trial Locations

Locations (1)

China Medical University Hospital; 🇨🇳 Taichung, Taiwan