Everyone Poops: An Evaluation of the Incidence and Risk Factors for Clostridioides Difficle Infection in Solid Organ Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 585
- 试验地点
- 1
- 主要终点
- Risk factors for CDI post-transplant - No.2
研究概览
简要总结
2.1. Study Objectives
- Primary Objective(s)
- Identify the incidence and risk of CDI within one year after kidney, liver, and/or pancreas transplant
- Secondary Objective(s)
- Identify the risk factors for recurrent CDI post-transplant in patients who were diagnosed with a CDI within one year prior to Solid Organ Transplant
- Evaluate the impact of CDI on graft survival following Solid Organ Transplant
详细描述
- Single center, retrospective cohort chart review study design
- Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018
- Will analyze outcomes from April 1, 2014 to July 31, 2019
- Patient list will be generated in Epic and Meditech
- All data will be obtained from Epic and Meditech
- All data will be collected retrospectively after the patient is discharged from the hospital
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Solid organ transplant patients who received graft(s) at MDMC from April 1, 2015 to July 31, 2018
- •Age >18 years old
排除标准
- •Age <18 years old
- •Loss to early death defined as within one week from transplantation
- •Patients whose primary address is in Puerto Rico
结局指标
主要结局
Risk factors for CDI post-transplant - No.2
时间窗: April 1, 2014 to July 31, 2019
Origin of transplanted graft including age of donor
Risk factors for CDI post-transplant No. 12
时间窗: April 1, 2014 to July 31, 2019
Antibiotic use in the 90 days post-transplant
Incidence of C. Difficile infection (CDI) within one year post-transplant
时间窗: April 1, 2014 to July 31, 2019
Incidence of C. Difficile infection within one year post-transplant for CDI post-transplant.
Risk factors for CDI post-transplant No.7
时间窗: April 1, 2014 to July 31, 2019
Co-infection with HIV/AIDS
Risk factors for CDI post-transplant - No.1
时间窗: April 1, 2014 to July 31, 2019
Risk factors transplanted organ
Risk factors for CDI post-transplant No.4
时间窗: April 1, 2014 to July 31, 2019
Acid suppression
Risk factors for CDI post-transplant No.5
时间窗: April 1, 2014 to July 31, 2019
First time SOT recipient
Risk factors for CDI post-transplant No.-3
时间窗: April 1, 2014 to July 31, 2019
Induction agent used
Risk factors for CDI post-transplant No.6
时间窗: April 1, 2014 to July 31, 2019
History of CDI in the year prior to transplant
Risk factors for CDI post-transplant No.8
时间窗: April 1, 2014 to July 31, 2019
Length of hospital stay
Risk factors for CDI post-transplant No. 9
时间窗: April 1, 2014 to July 31, 2019
Length of intensive care unit stay
Risk factors for CDI post-transplant No.10
时间窗: April 1, 2014 to July 31, 2019
Intra-operative administration of blood products
Risk factors for CDI post-transplant No. 11
时间窗: April 1, 2014 to July 31, 2019
Antibiotic use in the 90 days prior to infection
Risk factors for CDI post-transplant No, 13
时间窗: April 1, 2014 to July 31, 2019
Hospitalization in the 90 days prior to transplantation
Risk factors for CDI post-transplant No, 14
时间窗: April 1, 2014 to July 31, 2019
Hospitalization in the 90 days post-transplant
次要结局
未报告次要终点