GnRH for Luteal Support in IVF/ICSI/FET Cycles
- Registration Number
- NCT02357654
- Lead Sponsor
- University Reproductive Associates
- Brief Summary
During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .
- Detailed Description
see above
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 350
- women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old.
- day 3 transfers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo placebo - GnRH agonist GnRH -
- Primary Outcome Measures
Name Time Method Live birth per transfer 9 months
- Secondary Outcome Measures
Name Time Method clinical pregnancy 4 weeks rates of OHSS 4 weeks implantation rates 4 weeks
Trial Locations
- Locations (1)
University Reproductive Associates
🇺🇸Hasbrouck Heights, New Jersey, United States