GnRH for Luteal Support in IVF/ICSI/FET Cycles
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Live birth per transfer
研究概览
简要总结
During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .
详细描述
see above
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old.
排除标准
- •day 3 transfers
研究组 & 干预措施
GnRH agonist
干预措施: GnRH (Drug)
Placebo
干预措施: placebo (Drug)
结局指标
主要结局
Live birth per transfer
时间窗: 9 months
次要结局
- clinical pregnancy(4 weeks)
- rates of OHSS(4 weeks)
- implantation rates(4 weeks)