The Effects of Obesity and Weight Loss in Heart Failure: Imaging the Obesity Paradox Using Magnetic Resonance Imaging and Spectroscopy - Heart Failure With Preserved Ejection Fraction Substudy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- University of Oxford
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Left atrial volume
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study looks at the effects of weight loss in people who have heart failure with preserved ejection fraction (HFpEF) and are overweight or obese.
The main questions it aims to answer are whether weight loss in this group of people improves:
- The heart's shape, how well it pumps blood and how well it uses fuels
- The person's quality of life and how much they can exercise
Participants will attend 2 study visits, separated by 3-6 months. The intervention period takes place in between the 2 study visits.
Each study visit will involve measurements including:
- Symptom and quality of life questionnaires
- Body measurements such as height and weight
- Blood tests
- Ultrasound scans of the heart (echocardiogram)
- Magnetic Resonance Imaging (MRI) scans of the heart
- Exercise components during the scans
- 6 minute walk test
Participants are randomly allocated (in other words, by lottery) to either 'diet' or 'control' groups. The control group will continue standard care.
The diet group will be enrolled in a weight loss program supervised by the study team. Participants in the diet group will replace their usual meals with meal replacement products specifically designed to deliver a low calorie diet for weight loss. The products will consist of formula soups, shakes and porridges. This diet would last 8 weeks, followed by a guided period of food reintroduction and maintenance.
Detailed Description
An interim analysis is planned at 60 recruits to review the recruitment target.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Heart failure with preserved ejection fraction (HFpEF)
- •Left ventricular ejection fraction (LVEF) =/\> 50%
- •Body Mass Index (BMI) approximately =/\> 27.5 kg/m\^2
Exclusion Criteria
- •Contraindications to magnetic resonance imaging
- •NYHA class IV
- •Significant valvular, ischemic, infiltrative or other potentially confounding cardiac disease
- •Pregnancy, planned pregnancy or lactating
- •Any other conditions which may potentially compromise the safety or scientific validity of the study
Outcomes
Primary Outcomes
Left atrial volume
Time Frame: Change from baseline at 3-6 months
measured on cardiac magnetic resonance imaging
Secondary Outcomes
- Body weight(Change from baseline at 3-6 months)
- Six minute walk distance(Change from baseline at 3-6 months)
- N-terminal pro brain natriuretic peptide (NT pro BNP)(Change from baseline at 3-6 months)
- Kansas City Cardiomyopathy Questionnaire (KCCQ)(Change from baseline at 3-6 months)