A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery
- Registration Number
- NCT02113150
- Lead Sponsor
- Turkiye Yuksek Ihtisas Education and Research Hospital
- Brief Summary
In this prospective, randomized, clinical trial, we have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-c levels, and creatinine and/or cystatin-c based eGFR equations in terms of acute kidney injury in CABG surgery.This study was approved by the Ethics Committee of Hospital and all patients were informed and gave written consent. Patients scheduled for elective CABG with cardiopulmonary bypass. Patients were randomly allocated to anesthesia with remifentanil-propofol-midazolam (RPM) group or ketamine-propofol-midazolam (KPM) group. Blood samples were obtained before induction of anesthesia (baseline), at the end of the operation, and postoperative days 1, 2, and 4.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
patients undergoing elective CABG with cardiopulmonary bypass
patients undergoing emergency operation, combined operation, off-pump surgery, repeat surgery or valve surgery, patients presenting with chronic kidney disease or renal impairment, patients younger than 18 years old and neurological and/or psychiatric disturbances.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description remifentanil Ketamine remifentanil, short acting opioid ketamine remifentanil ketamine, intravenous anesthetic
- Primary Outcome Measures
Name Time Method creatinin, BUN 2 months
- Secondary Outcome Measures
Name Time Method Cystatin-c level 2 months
Trial Locations
- Locations (2)
Aslı Demir
🇹🇷Ankara, Turkey
Turkey Yuksek Ihtisas Education and Research Hospital
🇹🇷Ankara, Turkey