IRCT20140820018866N9招募中3 期
Evaluation of the Protective Effect of Metformin against the Tamoxifen Induced Changes on Endometrium and Ovaries in Women with Breast Cancer
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- no limit 至 no limit（—）
- 性别
- Female
入选标准
- •Adjutant treatment of breast cancer with tamoxifen
- •Normal pelvic exam
- •Performance state 0-2
排除标准
- •Serious diseases, heart or endocrine or other systemic diseases
- •Use of systemic hormone therapy during past 6 months
- •Alcohol consumption
- •Advanced breast cancer
- •Having any cancer or malignancy other than breast cancer during the last three years
- •Atypical hypoplasia or endometrial cancer
- •abnormal ovarian cysts with the possibility of malignancy on ultrasound
- •Contraindications for using metformin (eg: allergy to biguanides, acidosis, heart disease, alcohol consumption, gastroparesis, liver disease, hyperthyroidism or hypothyroidism, severe iron deficiency anemia, renal impairment)
- •Unbearable and dangerous side effects of metformin (such as: abdominal pain, chest pain, chills, cholestasis, severe diarrhea, dizziness, increased liver enzymes, severe headache, hepatitis, hypoglycemia, megaloblastic anemia, myalgia, palpitations, Skin rash and rash, vomiting)
研究者
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