A study on the effects of Lactobacillus brevis SBC8803 intake on skin in adults
- Conditions
- Dry skin
- Registration Number
- JPRN-UMIN000014327
- Lead Sponsor
- Total Technological Consultant Co., Ltd.(TTC)
- Brief Summary
The results of the present study revealed that following the analysis of the whole populations, marginal differences were observed in TEWL (for example, suppression of skin water loss) at the neck in the 25 mg/day group at week 8 and at the lower eye region in the 50 mg/day group at week 4 (P=0.05 and 0.09, respectively, compared with the placebo group analyzed by Dunnett's test). A significant increase in corneal hydration was also observed at the neck in the 25 mg/day group at week 12 (P=0.06, as compared with the placebo group as analyzed by Dunnett's test). In the analysis of the subpopulations whose habitual frequency of taking lactic fermentation products was less than once per week, the levels of corneal hydration at the neck (in the 50 mg/day group) and lower eye region (in the 25 mg/day group) were significantly increased at week 12 (P<0.05). In conclusion, the results of the present investigation suggest that oral intake of heat killed L. brevis SBC8803 is effective at improving skin hydration conditions in populations with low habitual frequency of taking lactic fermentation products.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Not provided
1. Subjects who have had lactobacillus-rich food, dietary supplements, or medicines constantly 2. Subjects who have used dietary supplements , medicines wchich affects skin constantly 3. Subjects who have treated cosmetic care 4. Subjects who treated cosmetic care except for measuring site or hormonal therapy 5. Subjects who got a facial, a wash-rag, lost hair, or plan these actions 6. Subjects who takes a medicine constantly 7. Subjects who plan to get a tan 8. Subjects who wash the body which provides strong skin irritation 9. Subjects who have a wound or a inflammatory disease 10. Subjects who diagnosed atopy or skin disorders 11. Subjects who have asthma or the possibility of asthma 12. Subjects who have a possibility of having hay fever and gettig a medicine, or is expecdted to develop a symptom of allergic states at the skin in the current study term 13. Subjects who feels to trouble by rough skin around a menstruates 14. Subjects who is employed on a pre-dawn shift or on night duty 15. Subjects who have diabetes, liver disease, kidney disease, or diseases wchich affects a secretion of sex hormones 16. Subjects who have participated in other clinical study 17. Subjects who are judged as unsuitable for the study based on the results of clinical and physical examination 18. Subjects who plans to become pregnant or lactate 19. Subjects who plans to go overseas 20. Subjects who have taken a blood sample or donated blood beyond the limit rules within the last one year prior to the screening test 21. Subjects who take measures affecting the results in current study, or don't stick to the rules 22. Subjects who are judged as unsuitable for the study based on the results of lifestyle questionnaire 23. Subjects who are judged as unsuitable for the study by physician for other reason
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transepidermal water loss
- Secondary Outcome Measures
Name Time Method Moisture content of the stratum corneum, skin conditions, questionnaire(skin, feces), Athens insomnia scale, Pittsburgh sleep quality index(Japanese)