Feasibility Study: Accuracy of Biomarker in Detection of Endometrial Cancer
- Conditions
- Endometrial CancerUterine Cancer
- Interventions
- Other: P2x7 assay
- Registration Number
- NCT00471120
- Lead Sponsor
- Dick Domanik
- Brief Summary
This study aims at developing an accurate, simple, and cost-effective method for screening and early detection of uterine cancers
- Detailed Description
The present study aims at developing an accurate, simple and cost-effective method for screening and early detection of uterine cancers in women using novel inventions and biotechnology methods for collection and assay of uterine cells. Results of P2X7 assays using tissues obtained from women with known uterine cancer and from women with histologically normal endometrium will be compared. These data will also serve as basis for future studies to test the predictive value of the method in population-based studies.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Female
- Target Recruitment
- 20
- women scheduled to undergo hysterectomy
- ages 18 years and older
- pregnant women
- students or employees under the direct supervision on the investigators.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description P2x7 Assay P2x7 assay Compare assay results with biopsy
- Primary Outcome Measures
Name Time Method To determine the accuracy potential of the P2X7 (protein and mRNA levels) for the detection of uterine endometrial cancers in women. Upon review of the assays.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (4)
University of Arkansas
🇺🇸Little Rock, Arkansas, United States
University Hospital CASE Medical Center
🇺🇸Cleveland, Ohio, United States
University of Texas
🇺🇸Galveston, Texas, United States
Eastern Virginia Medical School
🇺🇸Norfolk, Virginia, United States