Impact of Probiotic Regimen on Vancomycin Resistant Enterococcus Intestinal Carriage
- Conditions
- Vancomycin Resistant Enterococcus Intestinal Carriage
- Registration Number
- NCT00437580
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.
- Detailed Description
This study aims to reduce the duration of VRE intestinal carriage by the administration of Lactobacillus casei rhamnosus (strain Lcr 35 LC). Patients will be blindly randomized to be assigned to a 5 weeks regimen with the probiotic (10 9 lactobacillus bid) or to a 5 weeks regimen with placebo.A stool culture will be performed every week for 5 weeks (during the administration of treatment) then every two weeks until 3 consecutive negative stool culture for VRE.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 24
- Age >18;
- Vancomycin Resistant Enterococcus intestinal carriage
- Neutropenia <1000 /mm3,
- Immunosuppressive drugs,
- Inhalation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Reduction of the duration of Vancomycin Resistant Enterococcus intestinal carriage.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Service des Maladies infectieuses et tropicales
🇫🇷Hôpital Gabriel Montpied, Clermont-Ferrand, France