The Impact of a Caffeinated Sports Drink on Performance

Not Applicable

Recruiting

• Conditions: Dehydration; Dehydration Related to Exercise

• Registration Number: NCT06721793
• Lead Sponsor: Arizona State University

Brief Summary

Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance. This study evaluates a caffeinated electrolyte-glucose drink's effect on endurance, strength, and cognition. Using a repeated-measures, cross-over design, 20 trained cyclists will complete one familiarization and four randomized 3-hour experimental trials (Liquid I.V.™ Energy Multiplier, Hydration Multiplier, Sugar-Free Hydration Multiplier, and water). Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments. Cycling performance, capillary blood, urine, and expiratory gases will be collected.

Detailed Description

Each subject will complete 5 trials (1 familiarization and 4 experimental) consisting of approximately 2 hours cycling in a warm environment (90ºF), followed by strength assessment and cognitive assessment via questionnaire. Each trial will be identical, with the only difference being the type of drink consumed during each trial. The first trial will be for familiarization without any blood sampling. The rest of the trials will be completed in a randomized order and the drink consumed

Cycling Endurance Exercise Performance

The exercise test will consist of a series of three consecutive cycling sets in a warm environment (90ºF), with each series consisting of:

1. a 30-min submaximal ride (50% maximal power as determined from the initial)

2. a 5-km time trial race-like performance effort. During each 30 min submaximal rides participants will drink a total 500 mL of fluid spread out during the 30 min. During the 5 km performance test the participants will drink 25 mL of fluid at the end of each kilometer.

At regular intervals throughout the exercise task, body weight, blood samples, respiratory gasses, and perceptual data will be collected. See study schematic provided below for specific measurement timepoints.

Upon completion of the cycling task subjects will moved to another room with cool temperature (70ºF), where strength and cognitive function will be assessed to determine the influence of each beverage on indices of exercise performance and fatigue.

Study Timeline

• Study First Submitted: 2024-10-03
• Status Verified: 2024-12
• Study First Submitted QC: 2024-12-03
• Study First Posted: 2024-12-06
• Study Start: 2024-12-09
• Last Update Submitted: 2025-02-18
• Last Update Posted: 2025-02-19
• Primary Completion: 2025-05-31
• Study Completion: 2025-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age 18-55
• Healthy and injury-free (muscle, skeletal) for greater than 2 months
• Active cyclists who train at least 3 times per week
• Body mass index (BMI) range of 18.5-30 kg/m2

Exclusion Criteria

• • History of caffeine sensitivity

  • Cancer Diagnosis during the last 5 years
  • Pregnancy
  • History of renal disease, hypertension
  • History of a heat stroke
  • Use of testosterone therapy
  • Adults who are unable to consent (impaired decision-making capacity)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
5 kilometer cycling time trial	During the 3rd time trial which is the last time trial.	Time in minutes of completion the 5 kilometer cycling time trial at the 3rd exercise bout.
5 kilometer Time trial performance	2nd time trial	Time to completion the 2nd cycling time trial
Isokinetic stregth	right after the cycling tests	Peak torque at 60º/sec at dominant knee during extension
Congitive performance 1	after the completion of strength test	Attention Network Test score
Cognitive performance 2	after the end of the strength assessment	Working Memory Test score
Congitive test 3	right after the strength test	Stroop Task score

Secondary Outcome Measures

Name	Time	Method
Blood glucose	at the end of the 3rd cycling time trial.	Blood glucose levels during the 3rd cycling time trial.

Trial Locations

Locations (1)

Arizona State University - Hydration Science Lab; 🇺🇸 Phoenix, Arizona, United States