A comparison of doxycycline plus trimethoprim-sulphamethoxazole versus trimethoprim-sulphamethoxazole as maintenance therapy for melioidosis

Khon Kaen University (Thailand)0 个研究点目标入组 600 人开始时间: 2005年11月23日最近更新: 2016年10月17日

适应症

试验速览

暂无简介。

•1. Culture-confirmed melioidosis
•2. Satisfactory completion of intravenous therapy and able to take oral medication
•3. Patients with mild localised disease who are not considered to require intravenous treatment by their primary physician are eligible if they agree to return for follow up
•5. Aged over 14 years, either sex
•6. High likelihood of completing at least six months follow up
•7. Willingness to participate in the study and written, informed consent obtained from the patient

•1. Pregnancy or breast feeding
•2. Contraindications to doxycycline: severe hepatic impairment (aspartate aminotransferase [AST], alanine aminotransferase [ALT] more than or equal to five times of upper limit of normal)
•3. Contraindications to TMP-SMX: Glucose-6-phosphate dehydrogenase (G6PD) deficiency, renal impairment (creatinine clearance less than 15 ml/min)
•4. History of hypersensitivity to doxycycline, TMP or SMX
•5. Infecting isolate is resistant to TMP-SMX by E-test
•6. Relapse melioidosis with disease free interval of less than two years

发起方

Khon Kaen University (Thailand)