Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Patient Undergoing Breast Cancer Surgery :A Comparative Study
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- I.V patient controlled analgesia (PCA) morphine consumption
研究概览
简要总结
The Pecs block (pectoral nerves block) is an easy and reliable superficial block inspired by the infraclavicular block approach and the intercostal abdominis plane blocks . Many additives were used in combination with local anesthetics in Pecs block to prolong the postoperative analgesia (fentanyl, dexmedetomidine).
详细描述
60 patients scheduled for modified radical mastectomy surgery under general anesthesia. Group I (Bupivacaine group): patients underwent modified radical mastectomy were given preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles on the interfascial plane, and 20 ml injected between the Pectoralis minor muscle and the serratus muscle.Group II (Bupivacaine + Dexmedetomidine group) : preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) divided into 20 ml injected between the pectoralis muscles on the interfascial plane , and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I - II patients
- •weight 50- 100 kg
- •age 18-60 years
排除标准
- •History of bleeding diathesis
- •Relevant drug allergy
- •Opioid dependence
- •Those with psychiatric illnesses that would interfere with perception and assessment of pain will be excluded from the study
研究组 & 干预措施
Dexmedetomidine Injection [Precedex]
ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine Injection [Precedex] (1 µg/kg) divided into 20 ml injected between the pectoralis muscles and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.
干预措施: Dexmedetomidine Injection [Precedex] (Drug)
Group I (Bupivacaine group)
ultrasound guided modified Pec's block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles and 20 ml between the Pectoralis minor muscle and the serratus muscle
干预措施: Bupivacaine Injection [Marcaine] (Drug)
Dexmedetomidine Injection [Precedex]
ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine Injection [Precedex] (1 µg/kg) divided into 20 ml injected between the pectoralis muscles and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.
干预措施: Bupivacaine Injection [Marcaine] (Drug)
结局指标
主要结局
I.V patient controlled analgesia (PCA) morphine consumption
时间窗: 48 hours postoperative
the total dose of I.V patient controlled analgesia (PCA) morphine consumption in the first 48 hours postoperative
次要结局
- pain relief(48 hour)
研究者
Mohammed Farghaly Abd El hamid Ahmed
assisstant lecturer
South Egypt Cancer Institute