Treatment Interrupts Depression Early
- Conditions
- Depression
- Registration Number
- NCT05002309
- Lead Sponsor
- Nova Scotia Health Authority
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria:<br><br> - Age 12-25 years<br><br> - Diagnosis of major depressive disorder, onset of the major depressive disorder<br> within the last 12 months. Depression considered the most significant problem in<br> need of treatment.<br><br> - An additional inclusion criterion for entering Stage 1 (active intervention) is a<br> minimum moderate depression severity (CDRS-R=40; MADRS=20) that justifies the need<br> for treatment. Individuals who fulfill general inclusion criteria but are below the<br> depression severity threshold for active intervention will still be eligible to<br> participate in follow-up assessments.<br><br> - Verbal ability sufficient to participate in psychological treatment.<br><br>Exclusion Criteria:<br><br> - Personal history of a manic or hypomanic episode, diagnosis of a psychotic disorder,<br> pervasive developmental disorder or autism spectrum disorder, intellectual<br> disability, mental disorders secondary to neurological or other medical condition,<br> active substance use disorder.<br><br> - Previous trial of any treatment for major depressive disorder lasting 4 weeks or<br> longer, current use of antipsychotic, antidepressant or mood-stabilizer medication.<br><br> - Recent (past 6 weeks) change in any psychotropic medication (including stimulants,<br> hypnotics, anxiolytics) or receipt of 4 of more sessions of cognitive-behavioural<br> therapy.<br><br> - Pregnancy or breastfeeding. If participants become pregnant or learn of pregnancies<br> during the study, we will consult with Dr. Tanya Tulipan and jointly make the best<br> decision for the participant with the option to either continue or end study<br> treatment.<br><br> - No one will be excluded based on sex, gender, race, ethnicity, or living<br> arrangements.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of depressive symptoms;Severity of depressive symptoms;Proportion of time spent depression free
- Secondary Outcome Measures
Name Time Method Self-reported measure of depression.;Self-reported measure of generalized anxiety.;Self-reported measure of social anxiety.;Self-reported measures of general psychopathology.;Self-reported measure of quality of life.;Objective measures of psychopathology.;Objective measure of physical activity.;Objective measures of sleep.;Objective measures of educational progress.