Assessing the utility of CD34 expression as an immunohistochemical histopathological marker for tumour behavior in comparison to histopathological parameters and tumour,lymph node and metastatic staging in colorectal carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The study demonstrates that CD34 expression, as a marker of microvessel density (angiogenesis), shows a significant correlation with tumor aggressiveness in colorectal carcinoma.
研究概览
简要总结
Colorectal cancer is one of the common cancers and a major cause of death due to late diagnosis and aggressive tumor behavior One of the important factors responsible for tumor growth and spread is formation of new blood vessels This process is called angiogenesis CD34 is an important marker related to blood vessel formation and tumor progression Increased expression of CD34 is associated with aggressive tumor behavior advanced stage and poor prognosis
This study aims to evaluate CD34 expression in colorectal cancer using immunohistochemistry and correlate it with histopathological grade and TNM staging The study will include confirmed cases of colorectal carcinoma and assess CD34 expression in tumor tissue The results of this study will help in understanding tumor behavior identifying high risk cases and improving prognostic assessment and future treatment planning
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Already diagnosed as Colorectal carcinoma on histopathology.
- •2.All cases with colectomy /hemicolectomy/ abdominoperineal resection with suitable lymph node dissection.
- •3.Primary cases of Colorectal carcinoma without any history of previous treatment.
- •4.All patients with Colorectal carcinoma arising de novo.
排除标准
- •1.All benign lesions of colon and rectum and other malignant carcinomas like neuroendocrine tumors and gastrointestinal stromal tumor 2.All the already treated cases of Colorectal Carcinoma.
- •3.All patients with Colorectal carcinoma where the cancer is arising as a result of recurrence.
- •4.All patients who have defaulted treatment.
- •5.Patients with no histological confirmation of Colorectal Carcinoma.
结局指标
主要结局
The study demonstrates that CD34 expression, as a marker of microvessel density (angiogenesis), shows a significant correlation with tumor aggressiveness in colorectal carcinoma.
时间窗: 24 hours
次要结局
未报告次要终点
研究者
Dr Manya Puri
JNMC , Wardha