Effects of Different Ventilatory Strategy During Bronchoscopy

Not Applicable

Not yet recruiting

• Conditions: Bronchoscopy
• Interventions: Device: Supraglottic jet oxygenation and ventilation; Device: Conventional Oxygen Therapy; Device: High-flow nasal oxygen

• Registration Number: NCT05956301
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

The execution of diagnostic-therapeutic investigations by bronchial endoscopy can expose the patient to hypoxemia. For this reason, oxygen therapy is administered at low or high flows during the course of bronchoscopic procedures.

Our study aim was to evaluate the efficacy and complications of High-flow nasal oxygen (HFNO) via Supraglottic jet oxygenation and ventilation (SJOV)during flexible bronchoscopy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-06
• Study First Submitted QC: 2023-07-13
• Last Update Submitted: 2023-07-13
• Study Start: 2023-07-20
• Study First Posted: 2023-07-21
• Last Update Posted: 2023-07-21
• Primary Completion: 2025-06-30
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• need for bronchial endoscopy

Exclusion Criteria

• life-threatening cardiac aritmia or acute miocardical infarction within 6 weeks need for invasive or non invasive ventilation presence of pneumothorax or pulmonary enphisema or bullae recent (within 1 week) thoracic surgery presence of chest burns presence of tracheostomy pregnancy nasal or nasopharyngeal diseases dementia lack of consent or its withdrawal

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group III	Supraglottic jet oxygenation and ventilation	Supraglottic jet oxygenation and ventilation
Group I	Conventional Oxygen Therapy	Conventional Oxygen Therapy
Group II	High-flow nasal oxygen	High-flow nasal oxygen

Primary Outcome Measures

Name	Time	Method
Compare the intraoperative oxygenation.	During bronchoscopy, an average of 0.5 hour.	The study will monitor the SpO2， heart rate(HR) and mean arterial pressure (MAP) during the procedure.

Secondary Outcome Measures

Name	Time	Method
Arterial blood gases	At end of of bronchoscopy,an average of 0.5 hour after bronchoscope insertion.	Arterial blood gas analysis will be monitored at end of of procedure.
Assess the regional ventilation distribution by Electrical impedance tomography .	During bronchoscopy, an average of 0.5 hour.	Measurements will be done after bronchoscope insertion and at the end of the procedure.