Ablation of Ventricular Fibrillation by Accurate Targeting of Arrhythmogenic Regions (AVATAR)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- safety of ventricular basket mapping in patients undergoing ablation
研究概览
简要总结
This study will test the hypothesis that many human heart rhythm disorders are caused by small localized sources, where brief ablation may successfully eliminate the heart rhythm disorder.
详细描述
The investigators will enroll patients with documented rapid heart rates from the bottom chambers of the heart (ventricular tachyarrhythmias).
During electrophysiological study, the investigators will map the localized sources of these heart rhythm disorders.
- The 'active' group will prospectively receive brief ablation at localized sources (Focal Impulse and Rotor Modulation, FIRM).
- The control group will be a historical cohort who have received traditional ablation for this disorder.
All patients will be followed for up to 1 year to ensure that they have no recurrent arrhythmias.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 21 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Documented ventricular tachyarrhythmias.
- •Undergoing clinically indicated EP study with ablation.
排除标准
- •Unwillingness or inability to provide informed consent.
结局指标
主要结局
safety of ventricular basket mapping in patients undergoing ablation
时间窗: 1 month
To assess the incidence of adverse events arising from ablation using basket mapping in the ventricles. These include but are not limited to stroke, systemic thromboembolism, MI or acute coronary syndrome, groin complications, or death.
reduction in ventricular tachyarrhythmias events
时间窗: 3 months
Using careful clinical monitoring, we will compare the burden of VT/VF after ablation (including FIRM) to the burden preceding ablation.
次要结局
未报告次要终点