Uremic Toxin Removal, Blood Cell Kinetics, and Inflammatory Response in Patients Treated With the Allient System

Renal Research Institute3 sites in 1 country40 target enrollmentNovember 2008

ConditionsEnd Stage Renal Disease Chronic Kidney Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: End Stage Renal Disease
Sponsor: Renal Research Institute
Enrollment: 40
Locations: 3
Primary Endpoint: Clearance of specific waste products from blood determined through subject blood and dialysate samples
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of the study to determine whether the level of inflammation may be decreased, the lifespan of red blood cells increased and the clearance of waste products in the blood improved through the use of the Allient System as compared to conventional hemodialysis.

Registry

clinicaltrials.gov

Start Date

November 2008

End Date

January 2014

Last Updated

13 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Renal Research Institute

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Maintenance in-center hemodialysis
•Age greater than or equal to 18 years
•Has been on hemodialysis for at least 4 months
•Uses a standard single-pass dialysis machine with a high-flux dialyzer

Exclusion Criteria

•Hospitalization during the 8 weeks preceding enrollment
•Infection requiring antibiotic treatment during the 8 weeks preceding enrollment
•Central venous cather as dialysis access
•Uncontrollable blood coagulation anomalies
•Dialysis regimen other than 3 times weekly
•In ability to understand the English language and give informed consent for participation in the study

Outcomes

Primary Outcomes

Clearance of specific waste products from blood determined through subject blood and dialysate samples

Time Frame: 3 weeks

Secondary Outcomes

Inflammation as determined by levels of specific inflammatory markers(3 weeks)
Red blood cell lifespan determined through a measurement of CO in the subject's breath(3 weeks)