Idiopathic Pulmonary Fibrosis (IPF) and the 3 Minutes Sit-to-stand Test

Not Applicable

Completed

• Conditions: Idiopathic Pulmonary Fibrosis

• Registration Number: NCT03268915
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

This study is designed to evaluate the reproductibility and the performance of the 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis.

To do this, the investigators are recruiting 40 patients with idiopathic pulmonary fibrosis in 2 centers (Grenoble university hospital and Lyon university hospital).

Patients had to achieve an effort test on a cycle ergometer. 2 visits are planned in the hospital. During each visit, patients will perform a 3 minutes sit-to-stand test, a 1 minute sit-to-stand test and a 6 minutes walk test. During the second visit, patients will also perform a 3 minutes sit-to-stand test with measurement of oxygen uptake.

The investigators will then analyse the results by comparing numbers of cycle, functional response and symptoms during the 3 minutes sit-to-stand test of the 2 visits. The investigators will also compare the functional response obtained during the 3 minutes sit-to-stand test, the 1 minute sit-to-stand test and the 6 minutes walk test.

Finally, the investigators will compare the maximal values of oxygen uptake, respiration rate and expired volume obtained during the 3 minutes sit-to-stand test to the effort test on cycle ergometer.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-02-09
• Study First Submitted: 2017-07-21
• Study First Submitted QC: 2017-08-28
• Study First Posted: 2017-08-31
• Primary Completion: 2018-12-09
• Study Completion: 2018-12-09
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-07
• Last Update Posted: 2019-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• man or woman aged less than 85 years
• patients with Idiopathic Pulmonary Fibrosis without any acute exacerbation during 4 months before the inclusion
• Non-opposition to participation in research
• Patient with 6 minutes walk test > 200 meters (with or without oxygen therapy)

Exclusion Criteria

• Patient with reduced locomotor activity, or joint pain that compromises the performance of the tests
• Patient with 6 minutes walk test < 200 meters
• Patient with an other etiology of pulmonary fibrosis
• Other significant pulmonary diseases
• Patient with unstable cardiac disease
• Patient who may be, according to the investigator's assessment, not cooperating or respecting the obligations inherent in participating to the study.
• Opposition to participation in research

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Reproductibility of the 3 minutes sit-to-stand test in patient with idiopathic pulmonary fibrosis	2 days	Evaluate the reproductibility for the number of rise and down during the 3 minutes sit-to-stand test of the 2 visits (the investigators will compare the number of rise and sit during the 3 minutes sit-to-stand test of the 2 visits to see if they are similar)

Secondary Outcome Measures

Name	Time	Method
1 minute sit-to-stand test compared to 3 minutes sit-to-stand: oxygen saturation	2 days	Compared oxygen saturation during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test
Functional response during the 3 minutes sit-to-stand test: Heart rate	2 days	Evaluate the reproductibility of functional response (heart rate) during the 3 minutes sit-to-stand test
Functional response during the 3 minutes sit-to-stand test: symptoms	2 days	Evaluate the reproductibility of functional response (symptoms) during the 3 minutes sit-to-stand test
3 minutes sit-to-stand test compared to the 6 minutes walk test: symptoms	2 days	Compared symptoms during the 3 minutes sit-to-stand test to the 6 minutes walk test
Functional response during the 3 minutes sit-to-stand test: Oxygen saturation	2 days	Evaluate the reproductibility of functional response (oxygen saturation) during the 3 minutes sit-to-stand test
3 minutes sit-to-stand test compared to the 6 minutes walk test: oxygen saturation	2 days	compared oxygen saturation during the 3 minutes sit-to-stand test to the 6 minutes walk test
3 minutes sit-to-stand test compared to the 6 minutes walk test: heart rate	2 days	Compared heart rate during the 3 minutes sit-to-stand test to the 6 minutes walk test
1 minute sit-to-stand test compared to 3 minutes sit-to-stand: heart rate	2 days	Compared heart rate during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test
1 minute sit-to-stand test compared to 3 minutes sit-to-stand: symptoms	2 days	Compared symptoms during the 3 minutes sit-to-stand test with 1 minute sit-to-stand test

Trial Locations

Locations (2)

CHU Grenoble Alpes; 🇫🇷 La Tronche, France

Groupement Hospitalier Est; 🇫🇷 Lyon, France