Prospective Observational Cohort Study for Early Detection of Arteriosclerosis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 269
- 主要终点
- Cardiovascular events
研究概览
简要总结
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.
详细描述
About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.
At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years and older
- •informed consent
排除标准
- •life-threatening disease
- •life expectancy < 1 month
- •uncapable to provide informed consent
结局指标
主要结局
Cardiovascular events
时间窗: 10 years at least
次要结局
- Disease activity score(2 / 5 / 10 years)