NCT00115102CompletedPhase 4
Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Pain
Study Overview
Brief Summary
This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Diagnostic
- Masking
- Double
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Atypical odontalgia
Exclusion Criteria
- •BMI > 30
- •Heart conditions
- •Lung disease
- •Diseases of the liver or kidneys
- •Hypertension, untreated
Outcomes
Primary Outcomes
Pain
Sensitivity to heat and cold
Sensitivity to mechanical stimuli
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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