Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls
Phase 4
Completed
- Conditions
- Odontalgia
- Registration Number
- NCT00115102
- Lead Sponsor
- University of Aarhus
- Brief Summary
This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Atypical odontalgia
Exclusion Criteria
- BMI > 30
- Heart conditions
- Lung disease
- Diseases of the liver or kidneys
- Hypertension, untreated
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Pain Sensitivity to heat and cold Sensitivity to mechanical stimuli
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Danish Pain Research Center
🇩🇰Aarhus, Denmark