NL-OMON49023
Completed
Not Applicable
A Prospective, multicenter, observational study to identify deleterious novel variants of the DPYD gene in patients of non-Western descent: The DPYD-NOW study - Indentifying variants of DPYD in patients of non-Western descent
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cancer (breastcancer
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 22
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Pathologically confirmed malignancy for which treatment with a
- •fluoropyrimidine is considered to be in the patient\*s best interest
- •2\. Patients need to be self\-declared non\-Western
- •3\. Age \* 18 years
- •4\. Able and willing to give written informed consent;
- •5\. WHO performance status of 0, 1 or 2
- •6\. Life expectancy of at least 12 weeks
- •7\. Able and willing to undergo blood sampling for study related analysis
- •8\. Adequate baseline patient characteristics (complete blood count, hepatic
- •function which involves serum bilirubin, AST, ALT, and renal function)
Exclusion Criteria
- •1\. Prior treatment with fluoropyrimidines
- •2\. Patients with known substance abuse, psychotic disorders, and/or other
- •diseases expected to interfere with study or the patient\*s safety
Outcomes
Primary Outcomes
Not specified
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