Observational Study on the Use of Incretins in Diabetic Patients: Evaluation of Metabolic Effects and Cardiovascular Events
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,234
- 试验地点
- 1
- 主要终点
- Post-prandial plasma glucose
研究概览
简要总结
Observational, retrospective study, conducted in diabetic patients aimed to evaluate the effects on the glyco-metabolic control and on cardiovascular events of different DPP-4 inhibitors. Patients will be stratified in patients taking different DPP-4 in addition to sulfonylureas, biguanides, thiazolidinediones, insulin, compared to those in therapy with other hypoglycemic classes, such as sulphonylureas, biguanides, thiazolidinediones, insulin, alone or in combination, in primary and secondary prevention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetic patients
- •On oral hypoglycemic agents ± basal insulin
- •In primary and secondary prevention
排除标准
- •Patients with a follow-up of less than 8 years
研究组 & 干预措施
DPP-4 plus other therapies
Patients in therapy with DPP-4 inhibitors in addition to sulfonylureas and/or biguanides and/or thiazolidinediones and/or insulin
干预措施: DPP-4 inhibitors (Drug)
结局指标
主要结局
Post-prandial plasma glucose
时间窗: 8 years
mg/dl
Fasting plasma glucose
时间窗: 8 years
mg/dl
Glycated hemoglobin
时间窗: 8 years
Percentage
次要结局
- Fatal myocardial infarction(8 years)
- Atrial fibrillation(8 years)
- Cardiovascular death(8 years)
- Angina pectoris(8 years)
- Extrasystoles(8 years)
- Non-fatal myocardial infarction(8 years)
- Heart failure(8 years)
研究者
Giuseppe Derosa
Principal Investigator
University of Pavia