Evaluation of a potential human infection model of yellow fever using live attenuated yellow fever vaccine
Recruiting
- Conditions
- viral infectionYellow fever10047438
- Registration Number
- NL-OMON54831
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Healthy volunteers aged 18-50 years
Exclusion Criteria
Previous yellow fever vaccination, primary or secondary immunedeficiency,
thymus dysfunction (thymoma, thymectomy, thymus radiation, myastenia gravis,
DiGeorge syndrome), multipe sclerosis, pregnancy, chicken egg allergy, previous
allergic reaction to a compound present in the yellow fever vaccine, previous
vaccination with another live-attenuated vaccine within a period of 4 weeks
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary end point:<br /><br><br /><br>1. Percentage of participants with measurable viruria (yellow fever vaccine<br /><br>virus measurable in the urine) after yellow fever vaccination<br /><br>2. Peak of viruria after yellow fever vaccination</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. Hight of viruria<br /><br>2. Hight of antibody titers<br /><br>3. Hight if viremia<br /><br>4. Analysis of the innate immune response to yellow fever vaccine</p><br>