NCT00004840已完成不适用
Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm Infants
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)0 个研究点目标入组 996 人开始时间: 1998年5月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 996
研究概览
简要总结
OBJECTIVES:
I. Assess the efficacy and safety of antenatal administration of thyrotropin-releasing hormone to women in premature labor to improve pulmonary outcomes in preterm infants.
详细描述
PROTOCOL OUTLINE: This is a randomized, double blind, multicenter study. Patients are randomized to receive antenatal thyrotropin-releasing hormone or placebo.
Patients receive thyrotropin-releasing hormone or placebo intravenously over 20 minutes every 8 hours for 4 doses.
Infants are assessed for survival and chronic lung disease until day 28 after birth, and again at 36 postmenstrual weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant women in active labor with 24-29 weeks gestation
- •Not eligible if any of the following is present: Bleeding Infection Hypertension (greater than 140/90 mmHg) Fetus with hydrops or life-threatening anomalies One dead fetus in multiple pregnancy
排除标准
- 未提供
研究者
相似试验
已完成
2 期
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary AbnormalitiesHealthyPituitary DiseaseThyroid DiseaseNCT00054756National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)96
已完成
不适用
Thyroid Function in Term Infants With Respiratory DistressTransient HypothyroxinemiaInfant, NewbornNCT00293956Christiana Care Health Services20
已完成
3 期
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature DeliveryRespiratory Distress SyndromeNCT00004778National Center for Research Resources (NCRR)1,090
已完成
3 期
Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid WomenRecurrent Early Pregnancy LossThyroid DiseasesNCT06036576Al-Kindy College of Medicine77
已完成
不适用
The Yield of Postnatal Thyroid Function Test in the Well Baby NurseryHypothyroidismNCT05033496Hillel Yaffe Medical Center40,601