Exercise and Nerve Function in Diabetes
Not Applicable
Completed
- Conditions
- Diabetic Neuropathy
- Interventions
- Behavioral: Exercise
- Registration Number
- NCT00970060
- Lead Sponsor
- Patricia Kluding, PhD
- Brief Summary
The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.
- Detailed Description
The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- Age 40-70
- Type 2 diabetes
- Peripheral neuropathy
Exclusion Criteria
- Serious cardiac history or other medical problems that would prevent safe participation in exercise
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Exercise program Exercise Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.
- Primary Outcome Measures
Name Time Method Quantitative sensory testing 10 weeks Nerve conduction studies 10 weeks Proprioception 10 weeks Dermal and epidermal nerve fiber densities 10 weeks
- Secondary Outcome Measures
Name Time Method Clinical assessments of neuropathy, pain, body mass index, muscle strength, and glycemic control (glycosylated hemoglobin or A1C) 10 weeks
Trial Locations
- Locations (1)
Patricia Kluding PhD
🇺🇸Kansas City, Kansas, United States