Obstructive Sleep Apnea in Obese Children and Teenagers - Occurrence and Importance of Intervention
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sleep Apnea, Obstructive
- Sponsor
- Zealand University Hospital
- Enrollment
- 236
- Locations
- 2
- Primary Endpoint
- Change in obstructive sleep apnea (OSA)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The prevalence of childhood obesity has increased at an alarming rate over the last decades, both globally and in Denmark. There are a number of serious sequelae related to obesity, such as hypertension, hypercholesterolemia, fatty liver and prediabetes. Obesity is found to be a risk factor for obstructive sleep apnea (OSA). OSA in childhood is known to be associated with cardiovascular complications, neurocognitive problems and reduced quality of life. The correlation between obesity and OSA is still poorly understood. Early detection and intervention is of great importance as the health consequences related to OSA as well as obesity are severe. Adenotonsillectomy is recommended as first-line therapy in children with OSA. However, only around 25% of obese children benefit from this treatment compared to around 75% of normal-weight children suggesting that there might be other structural factors predisposing to OSA in obese children.
In this study the investigators aim to clarify the impact of obesity in the development of OSA. The prevalence of OSA in obese children will be investigated. Furthermore the purpose is to assess the effect of weight loss on OSA.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age: 7-18 years
- •BMI \> 90th percentile for age and gender
Exclusion Criteria
- •Neuromuscular disorders
- •Craniofacial syndromes / malformations
- •Laryngeal and tracheal malformations
Outcomes
Primary Outcomes
Change in obstructive sleep apnea (OSA)
Time Frame: One year
OSA will be diagnosed by cardiorespiratory measurement. The examination will be repeated after weight loss.