Effect of Bariatric Surgery-induced Weight Loss on Taste Perception
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Morbid Obesity
- Sponsor
- Washington University School of Medicine
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Changes on Taste Detection Thresholds After Bariatric Surgery-induced Weight Loss (Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Banding).
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The investigators wish to study the effects of three forms of bariatric surgery, gastric bypass lap banding, and sleeve gastrectomy. The surgery is not part of the clinical trial. If your insurance does not cover the procedure, then the patient is responsible for payment of the surgical process. The investigators are doing pre and post surgery testing to provide a better understanding of the effect of bariatric surgery-induced weight-loss on taste perception.
Detailed Description
Bariatric surgery is the most effective weight loss therapy for obesity. However, the mechanisms responsible for decreased food intake are incompletely understood. One possible mechanism that could account for decreased food intake is changes in taste perception. Therefore, the primary goal of this proposal is to provide a better understanding of the effects of bariatric surgery-induced weight-loss on taste perception.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI \>=35 kg/m²
- •on stable dose of medication for at least 4 weeks before the pre-surgery studies
Exclusion Criteria
- •smokes \> 7 cigarettes per day
- •previous malabsorptive or restrictive intestinal surgery
- •pregnant or breastfeeding
- •recent history of neoplasia (\< 5 years ago)
- •have malabsorptive syndromes and inflammatory intestinal disease
- •diabetes mellitus
- •show signs of oral disease or xerostomia (i.e. dry mouth)
- •history of chronic rhinitis
- •on medication that might affect taste
- •severe organ disfunction
Outcomes
Primary Outcomes
Changes on Taste Detection Thresholds After Bariatric Surgery-induced Weight Loss (Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Banding).
Time Frame: we will measure the above outcomes before surgery and at 20% weight loss post surgery, which on average we expect will occur around 3 months post-surgery
-Taste detection thresholds measures the lowest concentration of a tastant that can be detected (mili molar amounts).
Secondary Outcomes
- Changes on Emotional, External and Restricted Eating Behavior and Food Craving After Bariatric Surgery-induced Weight Loss (Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding).(we will measure the above outcomes before surgery and at 20% weight loss post surgery, which on average we expect will occur around 3 months post-surgery)