Genetics of Beta Cell Failure in Mexican Americans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,250
- 主要终点
- Pancreatic Beta Cell Compensation for Insulin Resistance
研究概览
简要总结
This is a family based genotype-phenotype study designed to assess genetic and environmental influences on obesity, insulin resistance and beta cell function in the context of gestational diabetes.
详细描述
Mexican American women with prior gestational diabetes and their first degree relatives and Mexican American women with prior normal glucose tolerance in pregnancy are studied with detailed phenotyping consisting of oral and intravenous glucose tolerance tests, body composition studies, diet and physical activity assessments, and circulating biomarkers potentially related to obesity, insulin resistance, pancreatic beta cell function, gestational diabetes and type 2 diabetes. Spouses of the gestational diabetic and control probands are studied with oral glucose tolerance tests. Offspring of the gestational and control probands have fasting glucose determinations. All participants provide DNA for genetics testing. A subset of the gestational diabetic probands and their first degree relatives return 3-5 years after baseline testing for repeat phenotyping.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Pancreatic Beta Cell Compensation for Insulin Resistance
时间窗: Single time point for primary cohort, repeated 4.5 years later in subset
Disposition index from intravenous glucose tolerance test
次要结局
- Insulin Senstivity(Single time point for primary cohort, repeated 4.5 years later in subset)
- Acute Insulin Release(Single time point for primary cohort, repeated 4.5 years later in subset)
- Diabetes type 2(Single time point for primary cohort, repeated 4.5 years later in subset)
- Glucose tolerance(Single time point for primary cohort, repeated 4.5 years later in subset)
- Physical Activity(Single time point for primary cohort, repeated 4.5 years later in subset)
- Body Fat(Single time point for primary cohort, repeated 4.5 years later in subset)
- Circulating adipokine levels(Single time point for primary cohort, repeated 4.5 years later in subset)
- Dietary Intake(Single time point for primary cohort, repeated 4.5 years later in subset)
研究者
Thomas Buchanan
Professor of Medicine
University of Southern California