NCT07592455已完成不适用
Correlation Between the Clinical Presentation of Pulp and the Biological Mediators in Gingival Crevicular Fluid and the Inflamed Pulpal Tissue
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- biological markers level
研究概览
简要总结
The aim of the present study was to Correlate between the clinical presentation of pulp and the biological mediators in gingival crevicular fluid and the inflamed pulpal tissue.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Systemically healthy male and female individuals aged between 18 and 50 years
- •No physical or mental disabilities
- •No underlying systemic diseases
- •Mandibular permanent premolar teeth diagnosed with symptomatic irreversible pulpitis with apical periodontitis
- •Mandibular permanent premolar teeth diagnosed with symptomatic irreversible pulpitis without apical periodontitis
- •Diagnosis based on the terminology of the American Association of Endodontists (2009)
- •Patients who provided written informed consent
- •Fully developed teeth with no previous pulp exposure
- •Positive response to cold testing
- •Positive response to electric pulp testing
排除标准
- •Requirement for antibiotic prophylaxis
- •Diabetes or hematologic disorders
- •Use of anti-inflammatory drugs, antibiotics, or antidepressants within the previous four weeks
- •Pregnancy at the time of treatment
- •Heavy plaque or calculus accumulation
- •Gingival redness and bleeding
- •Severe gingivitis or generalized periodontitis
- •Gingival pocket depths greater than 3 mm
- •Negative response to sensibility testing (cold test or electric pulp testing)
- •Presence of apical radiolucency (PAI > 2)
- •Previously initiated endodontic treatment
- •Internal or external root resorption
- •History of trauma
- •Severe calcific metamorphosis with obliterated root canal spaces on periapical radiographs
- •Vertical root fractures
- •Mobility greater than Grade I (Miller's mobility index)
- •Swelling or sinus tract associated with the treated tooth
- •Presence of periodontal-endodontic lesions
- •Teeth that could not be properly isolated with a dental dam
- •Collection of less than 10 µL of blood from each site
- •Conflicting clinical and radiographic findings preventing clear group assignment
- •No bleeding from one or more canal orifices (possible partial necrosis)
研究组 & 干预措施
lower premolars
Experimental
root canal treatment and samples of biomarkers
干预措施: root canal treatment (Procedure)
lower premolars
Experimental
root canal treatment and samples of biomarkers
干预措施: samples from Gingival crevicular fluid (Diagnostic Test)
control teeth / contralateral tooth
Active Comparator
samples of biomarkers
干预措施: root canal treatment (Procedure)
control teeth / contralateral tooth
Active Comparator
samples of biomarkers
干预措施: samples from Gingival crevicular fluid (Diagnostic Test)
结局指标
主要结局
biological markers level
时间窗: 2 months
TNF-alpha and sub P
次要结局
- Pain score through the Visual analogue scale(1 week)
- clinical presentation of irreversible pulpitis(1 week)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature MolarsNCT07340606Misr International University58
尚未招募
不适用
Comparison of two materials used to stop bleeding during treatment of deep tooth decay in children and their successCTRI/2026/02/104901Dr Reny Philip30
尚未招募
Phase 3 4
Comparision of three different root canal filling material in primary teeth- A clinical studyCTRI/2024/08/073092Dr Keerthana V60
尚未招募
3 期
Clinical and X-ray Evaluation of Three Different Materials for Treating Tooth Decay in Primary Molars: A Study in ChildrenCTRI/2024/10/07484479
招募中
不适用
Comparative evaluation between Direct pulp capping versus Pulpotomy in primary molarsCTRI/2024/08/072554Dr Vaishnavi Bele30