Oxymetazoline adds to the efficacy of Fluticasone furoate in the treatment of persistent rhinitis
Phase 4
Recruiting
- Conditions
- Persistent rhinitis (includes allergic rhinitis and non-allergic rhinitis)Allergic rhinitisNon-allergic rhinitis
- Registration Number
- TCTR20210221003
- Lead Sponsor
- the Faculty of Medicine, Prince of Songkla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
1. Patients aged between 15 and 65 years
2. Had rhinitis symptoms: two or more symptoms of nasal obstruction, rhinorrhea, and
sneezing and/or nasal itching
3. persistent symptom for at least 3 months
Exclusion Criteria
1. Had used intranasal or inhaled or systemic steroids within 1 month
2. Had used systemic steroids within 2 months
3. Had used decongestion or antihistamines within 7 days
4. Had undergone sinonasal surgery or immunotherapy
5. Symptoms or physical signs suggestive of renal, hepatic, or
cardiovascular disease, concomitant sinusitis, nasal polyposis,
and septal deviation.
6. Recent URI within past 4 weeks
7 Contraindication to allergy skin test
8. Current smokers
9. Contraindication to corticosteroids and decongestants
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method asal symptoms At 0, 4 and 6 weeks after treatment nasal symptoms score
- Secondary Outcome Measures
Name Time Method asal and oral peak inspiratory/expiratory flow rate At 0, 4 and 6 weeks after treatment L/min, ratio,Nasal mucocilliary clearance time At 0, 4 and 6 weeks after treatment minutes,Nasal cytology At 0, 4 and 6 weeks after treatment Cells