NCT06054529进行中（未招募）不适用
Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients
AdventHealth Translational Research Institute1 个研究点 分布在 1 个国家目标入组 2 人开始时间: 2023年9月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Subtyping of GBM tumors as Classical, Proneural or MES (based on RNA-seq)
研究概览
简要总结
To learn how altered metabolism in GBM causes tumor growth and resistance to drug therapy. In this pilot research study, we will dose GBM patients with a form of nicotinamide (a natural vitamin) that we can track. The nicotinamide will be converted to methyl nicotinamide (MeNAM) in the tumor. We will measure how fast the nicotinamide is converted to methyl nicotinamide. We believe that the speed of this chemical reaction in the tumor (fast versus slow) may be correlated with GBM aggressiveness
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preoperative MRI consistent with a primary intracranial malignant brain tumor.
- •Must be 18 years of age or older.
- •Patient eligible for debulking surgery/resection.
排除标准
- •Inability to obtain pre-operative IV access.
- •Use of Tru Niagen, Basis (or any other nicotinamide riboside (NR)-containing NAD+ booster) or niacin supplements within one month prior to Study Visit
- •Participation in studies involving investigational drug(s) within 30 days prior to Study Visit 1
- •Blood donation (excluding plasma donations) of approximately 1 pint (500 mL) or more within 56 days prior to Study Visit 1 (participants may not donate blood any time during the study, through the final study day)
- •Presence of any condition that, in the opinion of Dr. Field, compromises participant safety or data integrity or the participant's ability to complete study days.
- •Pregnancy, lactation or < 9 months postpartum from the Study Visit 1 date.
结局指标
主要结局
Subtyping of GBM tumors as Classical, Proneural or MES (based on RNA-seq)
时间窗: 2 months
Resected tumor tissue will undergo routine testing
次要结局
未报告次要终点
研究者
研究点 (1)
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