The Effects of Three Different Modalities of Exercise in Patients With Schizophrenia

Not Applicable

Completed

• Conditions: Schizophrenia
• Interventions: Other: Experimental-Exercise training

• Registration Number: NCT03953664
• Lead Sponsor: Cardenal Herrera University

Brief Summary

Exercise has been shown to improve health in patients with schizophrenia. However, it remains unclear which modality of exercise reports better benefits.

Aim: To compare the effects of different modalities of exercise training on psychological and physiological variables in schizophrenia.

Detailed Description

Exercise has been shown to improve psychological, physiological, and biological correlates in patients with schizophrenia. However, it remains unclear which modality of exercise reports better health benefits.

Aim: To compare the effects of three different modalities of exercise (aerobic, strength, aerobic-strength) on psychological and physiological variables in patients with schizophrenia.

Design: Randomized clinical trial

Study Timeline

• Study First Submitted: 2019-05-15
• Study First Submitted QC: 2019-05-15
• Study First Posted: 2019-05-16
• Study Start: 2020-01-14
• Primary Completion: 2021-04-01
• Study Completion: 2021-04-01
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-27
• Last Update Posted: 2021-06-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Diagnosis of Schizophrenia
• Age between 18-65 years

Exclusion Criteria

• Patients with other mental diseases
• Patients with mental disabilities
• Patients who present motor or behavioral pathologies that prevent the realization of the exercise training.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental-Aerobic training	Experimental-Exercise training	Each session lass 60 minutes, during which time 20 minutes are allocated for warming up and cooling down (stretching) and 40 minutes are allocated to brisk walking.
Experimental-Strength training	Experimental-Exercise training	Each session lass 60 minutes, during which time 20 minutes are allocated for warming up and cooling down (stretching) and 40 minutes are allocated to strength training exercise involving the major muscle groups.
Experimental-Strength/Aerobic training	Experimental-Exercise training	Each session lass 60 minutes, during which time 20 minutes are allocated for warming up and cooling down (stretching), 15 minutes are allocated to brisk walking and 25 minutes are allocated to strength training involving the major muscle groups.

Primary Outcome Measures

Name	Time	Method
Positive and Negative Syndrome Scale (PANSS)	16 weeks	Symptoms of schizophrenia are measured according to the subscale scores and total score on the PANSS which consists of 30 items scored from 1 (Absent) to 7 (Extreme). Scores range from 30 to 210, with higher scores indicating more symptoms.

Secondary Outcome Measures

Name	Time	Method
World Health Organization Quality of Life-Short version (WHOQOL-BREF)	16 weeks	The WHOQOL-BREF contains 24 questions covering 4 domains plus two questions related to overall quality of life and satisfaction with health. Highes scores represent higher quality of life.
Body Mass Index (BMI)	16 weeks	The BMI is defined as the body mass divided by the square of the body height.

Trial Locations

Locations (1)

Universidad CEU Cardenal Herrera; 🇪🇸 Moncada, Valencia, Spain