Evaluation of the effect of high protein-weight loss diet combined with beta cryptoxanthin supplement on metabolic factors, serum levels of oxidants, inflammatory and adipocytokins among patients with nonalcoholic fatty liver disease.

Ahvaz Jundishapur University of Medical Sciences0 个研究点目标入组 92 人开始时间: 待定最近更新: 2018年2月22日

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•Inclusion criteria will be included: subjects will be overweight and obese (25=BMI =40) individuals aged between 18–60 years of both genders, existence of NAFLD by ultrasound, NAFLD activity score less than 3, and willingness to participate. subjects with viral hepatitis, cirrhosis, Wilson's disease, acute fatty liver of pregnancy, hepatocellular carcinoma, hypothyroidism and a history of chronic liver disease, lipodystrophy, menopause, parenteral nutrition, bladder and bile duct disease, significant weight loss (=10% of body weight during 6 months ago) or weight loss surgery, Congenital metabolic diseases, subjects on antioxidant supplementations, milk thistle and omega-3 fatty acids in the 6 months ago, a history of liver damaging drugs (amiodarone, anti-virus, aspirin, non-steroidal anti-inflammatories, corticosteroids, methotrexate, tamoxifen, tetracycline, valproic acid), alcohol consumption >20 g/day, calorie intake less than 800 kcal or more than 4200 a day, pregnancy and lactation, serum ALT levels more than five times of the upper limit (maximum limit of 30 for women and 40 for men), history of cardiovascular and kidney disease (urine analysis Albumina = 30 (mg / 24 h) and GFR = 90 ml / min / 1.73 m2) will be not included.

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