The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery - Assessment With Pulmonary Arterial Catheter and Transesophageal Echocardiography Measurements
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tampere University Hospital
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Tricuspid annular plane systolic excursion (TAPSE)
Study Overview
Brief Summary
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.
Detailed Description
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •scheduled mitral valve prolapse repair surgery
- •able to give informed consent
Exclusion Criteria
- •preoperative right ventricular dysfunction or pulmonary hypertension
- •significant tricuspid regurgitation
- •congenital heart defect
- •ventricular dyssynchrony or wide QRS-complex on ECG (> 130 ms)
- •prior myocardial infarction (within tree months) or pericardial constriction
- •preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 %
- •if the scheduled repair by plastic procedure has been converted to mitral valve replacement
Arms & Interventions
Hypercarbia
Hypercarbia: PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation.
Intervention: Hypercarbia (Procedure)
Outcomes
Primary Outcomes
Tricuspid annular plane systolic excursion (TAPSE)
Time Frame: Change from baseline TAPSE at hypercarbia (in approximately 30 min)
TAPSE will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
Mean pulmonary artery pressure (MPAP)
Time Frame: Change from baseline MPAP at hypercarbia (in approximately 30 min)
MPAP will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
Secondary Outcomes
No secondary outcomes reported
Investigators
Kati Järvelä
MD, PhD
Tampere University Hospital