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Clinical Trials/ACTRN12622000447752
ACTRN12622000447752Recruiting未知

A randomised trial evaluating the effect of phylloquinone on the progression of mild to moderate aortic stenosis

niversity of Western Australia0 sites108 target enrollmentStarted: March 21, 2022Last updated:
Conditions

Trial Snapshot

Phase
未知
Status
Recruiting
Sponsor
Enrollment
108

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional
Allocation
Randomised controlled trial
Primary Purpose
Prevention
Masking
Blinded (masking used)

Eligibility Criteria

Ages
18 Years to o limit (—)
Sex
All

Inclusion Criteria

  • 1) Aged 18+ years
  • 2) Mild to moderate calcific aortic stenosis (peak flow velocity greater than 2.5m/s and less than 4m/s)
  • 3) Valve area greater than 1 cm2
  • 4) At least mild aortic valve calcification (Rosenhek category=1) on echocardiography.

Exclusion Criteria

  • 1) Planned procedure to unblock heart arteries
  • 2) Clinically important disease of any heart valve
  • 3) Kidney disease (eGFR<40ml/min)
  • 4) Intolerance to Vitamin-K
  • 5) Prescribed a Vitamin-K blocker or supplement
  • 6) Heart rhythm disturbance preventing a good quality CT-calcium score scan
  • 7) Pregnancy
  • 8) Unlikely to complete the 12 months follow-up.

Investigators

Sponsor
niversity of Western Australia

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