Effect of topical silver sulfadiazine-cerium nitrate in treatment of moderate to severe bur

Phase 3

Recruiting

Conditions: Burns and corrosions.
Burn of unspecified body region, unspecified degree
T29.0

Registration Number: IRCT20190927044902N1

Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 112

Inclusion Criteria

Second and third degree burns according to Laund & Browder criteria
Minimum burn rate of patients is 10% and maximum of 50%
Patients are being hospitalized in the first 24 hours of a hospital bed.
informed consent to enter the study .

Exclusion Criteria

Inhalation burn
Electrical and chemical burns
Burns on face and hands and perineum
A history of known allergies to sulfonamides
History of Methemoglobinemia
Pregnancy and lactation
G6PD deficiency
Oliguria and Anuria
Functional liver disorders
Lack of satisfaction with the patient to enter or continue intervention

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
90% Re-epithelialization as complete restoration. Timepoint: 7, 14, 21 and 28 days after onset of treatment with formulation. Method of measurement: The Re-epithelialization rate will also be recorded as very slow (5-6 weeks), slow (about 4 weeks), moderate (2-3 weeks), or fast (about 10 days).

Secondary Outcome Measures

Name	Time	Method
The pain of the patient. Timepoint: once every three days. Method of measurement: The use of the visual pain criterion will be evaluated and will be graded from 0-10.;Duration of hospitalization. Timepoint: Every 5 days. Method of measurement: Based on the percentage of grafts taken on day 5.;Infection frequency. Timepoint: Every week. Method of measurement: Wound culture.